Gonadorelin Injection 1 mg

Therapeutic Profile

• Active Compound: Synthetic gonadotropin-releasing hormone (GnRH)

• Concentration: 1 mg/mL lyophilized powder (reconstituted)

• Mechanism: Pulsatile action stimulates pituitary release of LH/FSH

Clinical Indications

✔ Hypogonadotropic Hypogonadism (Diagnostic & Therapeutic)
✔ Fertility Assessment (Pituitary Function Test)
✔ HPTA Axis Restoration (Post-Steroid Recovery)
✔ Controlled Ovarian Stimulation (Adjuvant in IVF)

Dosing Protocols

For Men (Hormone Optimization)

• Testicular Axis Stimulation: 50–100 mcg SC daily

• PCT Support: 100 mcg 2–3x/week (with hCG)

For Women (Ovulation Induction)

• Pulse Dosing: 5–20 mcg IV/SC every 90 min (pump-administered)

• Follicular Phase Support: 100 mcg/day IM

Administration Guide

• Reconstitution: Sterile NaCl 0.9% (avoid preservatives)

• Injection Sites: Subcutaneous (abdomen) or IM (gluteal)

• Timing: AM administration mimics natural secretion

Pharmacokinetics

• Onset: LH surge within 15–45 min (IV), 2–4 hr (SC)

• Half-life: 4–8 minutes (IV), 10–15 min (SC)

• Excretion: Renal clearance (monitor in CKD)

Safety & Monitoring

⚠ Adverse Effects:

• Transient headache/flushing (histamine-mediated)

• Rare pituitary hemorrhage (high-dose risk)

🔬 Required Labs:

• Baseline & 24-hr post-injection LH/FSH (diagnostic use)

• Testosterone/Estradiol monitoring (therapeutic use)

Advantages Over Alternatives

→ Preserves natural pulsatile GnRH secretion
→ No receptor desensitization (vs. leuprolide)
→ Compatible with hCG/clomiphene protocols

Rx Note: *Single-use vials only. Discard reconstituted solution after 24 hr refrigerated. Not for continuous infusion >21 days.*

Pregnancy Category: C (contraindicated in ovarian hyperstimulation)