Sildenafil Tablet 10mg 20mg 25mg 50mg 100mg/piece

Sildenafil citrate tablets remain the first-line oral therapy for erectile dysfunction (ED), offering flexible dosing from mild enhancement (10mg) to maximum clinical effect (100mg). These immediate-release tablets inhibit PDE5 to amplify nitric oxide-mediated vasodilation, with proven efficacy across all ED etiologies.

Key Strengths by Dose:

• 10mg – Low-dose option for:
  • First-time users testing tolerance
  • Combined with other agents (e.g., testosterone)
  • Daily microdosing protocols

• 20-25mg – Intermediate dosing for:
  • Mild-to-moderate ED
  • Younger patients with situational ED
  • Those taking concurrent alpha-blockers

• 50mg – Standard therapeutic dose:
  • Balanced efficacy/safety profile
  • Most common starting dose

• 100mg – Maximum approved dose:
  • Severe ED cases
  • Non-responders to lower doses
  • Limited to once-daily use

Clinical Protocol:

• Administration: Swallow whole with water

• Onset: 30-60 minutes (faster when fasting)

• Duration: 4-6 hour effective window

• Dosing Frequency:

  • 10-25mg: May be used daily

  • 50-100mg: Max 1x/24 hours

Critical Safety Notes:
⚠ Absolute Contraindications:
• Concurrent nitrate/nitrite use (risk of severe hypotension)
• Recent stroke/MI (<6 months)
• Hereditary retinal disorders (e.g., retinitis pigmentosa)

⚠ Dose-Specific Considerations:

• 100mg: Higher risk of:
  • Severe headache (15% incidence)
  • Visual disturbances (dose-dependent)
  • Hypotension with alpha-blockers

Comparative Advantages:
→ More rapid onset than tadalafil (but shorter duration)
→ Lower cost than newer PDE5 inhibitors
→ Extensive real-world safety data (25+ years clinical use)

Patient Optimization Tips:
✔ Take on empty stomach (high-fat meals delay absorption)
✔ Avoid grapefruit juice (increases AUC by 23%)
✔ Consider 25mg trial dose if:
• Age >65
• Hepatic impairment
• Concurrent CYP3A4 inhibitors

Storage Requirements:

• Room temperature (15-30°C)

• Protect from moisture

• Original packaging protects from light

Prescribing Insights:

• Start low (25-50mg) unless severe ED

• Reassess at 4-8 weeks – many non-responders benefit from dose escalation

• Check testosterone if suboptimal response to 100mg