Shope
Trimix (Alprostadil/papaverine) 5ml
$191.00
A compounded injectable solution combining three synergistic vasoactive agents for severe erectile dysfunction cases unresponsive to oral PDE5 inhibitors. Delivers rapid, reliable erections through direct smooth muscle relaxation and arterial dilation.
Mechanism of Action
| Component | Concentration | Primary Effect |
|---|---|---|
| Alprostadil | 30mcg/mL | Prostaglandin E1 → cAMP-mediated dilation |
| Papaverine | 30mg/mL | Non-specific PDE inhibition → cGMP/cAMP ↑ |
| Phentolamine | 1mg/mL | α-adrenergic blockade → reduced outflow |
Clinical Indications
✔ PDE5 inhibitor failures
✔ Post-prostatectomy ED (nerve-sparing or non-nerve-sparing)
✔ Vascular insufficiency-related ED
✔ Psychological ED with vasculogenic component
Dosing Protocol
Initial Test Dose: 0.1mL (3mcg/3mg/0.1mg)
Titration: Increase by 0.05mL increments to find minimal effective dose
Typical Range: 0.2-0.5mL (6-15mcg/6-15mg/0.2-0.5mg)
Max Dose: 1mL (30mcg/30mg/1mg)
Administration:
Use 29-31G insulin syringe
Inject laterally at 10 or 2 o'clock position
Alternate sides between uses
Safety & Monitoring
⚠ Absolute Contraindications:
Penile implants/anomalies
Sickle cell anemia
Severe cardiovascular instability
⚠ Risk Mitigation:
Priapism Protocol:
4 hours → oral pseudoephedrine 60mg
6 hours → ER aspiration + phenylephrine irrigation
Required Training:
✔ Proper injection technique
✔ Post-injection compression (2 min)
✔ Recognizing prolonged erection
Comparative Efficacy
| Parameter | TRIMIX T105 | Alprostadil Alone |
|---|---|---|
| Response Rate | 92% | 72% |
| Onset Time | 5-15 min | 10-20 min |
| Duration | 60-90 min | 30-60 min |
Advantages Over Bimix
→ Lower alprostadil dose reduces pain risk
→ Phentolamine counters vasoconstriction
→ More predictable than papaverine monotherapy
Storage & Stability
Unopened: 12 months frozen (-20°C)
In Use: 30 days refrigerated (2-8°C)
Avoid: Repeated freeze-thaw cycles
Prescribing Considerations:
• Start with T60 (half-strength) for neurogenic ED
• Combine with VSS (visual sexual stimulation) for psychogenic component
• Regular penile Doppler US monitoring recommended
PRODUCT INFO
A compounded injectable solution combining three synergistic vasoactive agents for severe erectile dysfunction cases unresponsive to oral PDE5 inhibitors. Delivers rapid, reliable erections through direct smooth muscle relaxation and arterial dilation.
RETURN & REFUND POLICY
At Coded Wellness, we are committed to providing a fair and transparent process for our patients. Prescription medications are non-returnable and non-refundable once they have been dispensed, in compliance with pharmacy regulations. If your order arrives damaged, defective, or incorrect, please contact us right away and we will work with you to resolve the issue promptly. Our goal is to ensure every order is handled with care and that your experience with us is simple and stress-free.
SHIPPING INFO
At Coded Wellness, we work with trusted U.S. compounding pharmacies to deliver safe, high-quality medications directly to your door. We provide convenient shipping within select states across the United States, ensuring fast and reliable delivery so you can stay on track with your treatment plan.