Vardenafil Troche

Overview:
A specialized troche formulation of vardenafil (5mg/10mg/20mg) designed for sublingual/buccal absorption, offering faster onset than oral tablets while avoiding first-pass metabolism. This discreet, needle-free option is ideal for patients seeking:

• Quicker results (15-25 minute onset)

• Reduced GI side effects

• Alternative to swallowing pills

Key Advantages:
✔ Enhanced Bioavailability (Bypasses hepatic metabolism)
✔ Precise Dosing (Flexible 5-20mg strengths)
✔ Discreet Administration (No water needed)

Clinical Protocol:

• Dosing:

  • First-time users: Start with 5mg troche

  • Standard dose: 10mg dissolved sublingually

  • Maximum: 20mg/24hr

• Administration:

  • Place troche under tongue or in cheek pouch

  • Allow complete dissolution (~10-15min)

  • Avoid eating/drinking during absorption

• Timing:

  • Effective within 15-25 minutes

  • Optimal window: 1-6 hours post-dose

Comparative Pharmacokinetics:

Safety Profile:
⚠ Contraindications:

• Concurrent nitrate use

• Severe hepatic impairment

• Hereditary retinal disorders

⚠ Troche-Specific Notes:

• May cause transient oral numbness

• Bitter taste (flavoring options available)

• Higher peak concentrations than oral tablets

Ideal Candidates:
• Patients needing rapid onset
• Those with gastric absorption issues
• Individuals preferring non-pill formats

Compounding Benefits:
→ Can be combined with:

• Lidocaine (for premature ejaculation)

• Testosterone (for hypogonadal patients)
  → Customizable flavors

Storage:

• Refrigerate (2-8°C) for 90-day stability

• Protect from moisture

Patient Counseling:
✔ "Dissolve completely - don't chew/swallow"
✔ "Avoid alcohol with first doses"
✔ "Prime dosing at home before actual use"

Why Choose Troche Over Tablets?
→ 50% faster onset than oral vardenafil
→ 30% higher bioavailability
→ Preferred by patients with:

• Gastric bypass surgery

• Pill dysphagia

• Need for discretion